Main
Xudong Wang, Ph.D.
My academic training and research experiences have provided me with a solid background in multiple biological disciplines including biochemistry, molecular biology, immunology, and proteomics.
My long-term interest is to employ cutting-edge biotechnologies and computer science to elucidate the fundamental mechanisms of biology systems.
Education
Postdoctoral Researcher
UT Southwestern Medical Center
Dallas, TX, USA
Present - 2015
Ph.D., Biochemistry and Molecular Biology
Sun Yat-sen University
Guangzhou, China
2015 - 2008
B.Sc., Applied Chemistry
School of Chemistry, Central China Normal University
Wuhan, China
2008 - 2004
B.Sc., Biotechnology (Dual degree)
Life Science School, Central China Normal University
Wuhan, China
2008 - 2004
Research Experience
Postdoctoral Research Jobs and Projects
N/A
N/A
Present - 2016
- Independent development of MS-based assays, data analysis, and presenting data to the team
- Systematically characterized the mTOR-regulated secretome by a quantitative proteomic approach, deciphering the molecular basis of mTORC1-mediated feedback loops
- Contributed to mass spectrometry-based screening strategies, including an ultra-fast HTMS screening for identification and characterization small covalent binding molecule modulators to support hit to lead programs from multiple therapeutic areas
Ph.D. Projects
N/A
N/A
2015 - 2008
- Focused on a novel PTM (sumoylation) in TCR-induced T cell synapse organization and T cell activation
Undergraduate research assistant
N/A
N/A
2008 - 2007
- In-Vitro Expression and Functional Analyses of TAK1 Isoforms
Featured Publications
The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1
EMBO reports
N/A
2020
Wang, Xu-Dong ; Zhao, Chen-Si; Wang, Qi-Long; Zeng, Qi; Feng, Xing-Zhi; Li, Lianbo; Chen, Zhi-Long; Gong, Yu; Han, Jiahuai; Li, Yingqiu
Machine Learning for Cancer Subtype Prediction with FSA Method
International Conference on Smart Computing and Communication
N/A
2019
- Liu, Yan;
Wang, Xu-Dong ; Qiu, Meikang; Zhao, Hui
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
Nature communications
N/A
2019
Wang, Xu-Dong ; Hu, Rongkuan; Ding, Qing; Savage, Trisha K; Huffman, Kenneth E; Williams, Noelle; Cobb, Melanie H; Minna, John D; Johnson, Jane E; Yu, YonghaoEditors’ Selection for Lung Cancer Awareness Month in Nov 2019 1
TCR-induced sumoylation of the kinase PKC-theta controls T cell synapse organization and T cell activation
Nature immunology
N/A
2015
Wang, Xu-Dong ; Gong, Yu; Chen, Zhi-Long; Gong, Bei-Ni; Xie, Ji-Ji; Zhong, Chuan-Qi; Wang, Qi-Long; Diao, Liang-Hui; Xu, Anlong; Han, JiahuaiScience Signaling Editors’ Choice2
Other Publications
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
Nucleic Acids Research
N/A
2021
- Jia, Jian-Jun; Lahr, Roni M; Solgaard, Michael T; Moraes, Bruno J; Pointet, Roberta; Yang, An-Dao; Celucci, Giovanna; Graber, Tyson E; Hoang, Huy-Dung; Niklaus, Marius R; Pena, Izabella A; Hollensen, Anne K; Smith, Ewan M; Chaker-Margot, Malik; Anton, Leonie; Dajadian, Christopher; Livingstone, Mark; Hearnden, Jaclyn;
Wang, Xu-Dong ; Yu, Yonghao; Maier, Timm; Damgaard, Christian K; Berman, Andrea J; Alain, Tommy; Fonseca, Bruno D
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
Elife
N/A
2020
- Kim, Chiho;
Wang, Xu-Dong ; Yu, Yonghao;
Autophagy and Epigenetics
Autophagy and Cardiometabolic Diseases - From Molecular Mechanisms to Translational Medicine
N/A
2018
Wang, Xu-Dong ; Gillette, Thomas G.; Wang, Zhao V.;
LARP1 is a major phosphorylation substrate of mTORC1
BioRxiv
N/A
2018
- Fonseca, Bruno D; Jia, Jian-Jun; Hollensen, Anne K; Pointet, Roberta; Hoang, Huy-Dung; Niklaus, Marius R; Pena, Izabella A; Lahr, Roni M; Smith, Ewan M; Hearnden, Jaclyn;
Wang, Xu-Dong ; Yang, An-Dao; Celucci, Giovanna; Graber, Tyson E; Dajadian, Christopher; Yu, Yonghao; Damgaard, Christian K; Berman, Andrea J; Alain, Tommy
MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis
Molecular cancer
N/A
2017
- Yang, Yan; Ding, Lili; Hu, Qun; Xia, Jia; Sun, Junjie;
Wang, Xu-Dong ; Xiong, Hua; Gurbani, Deepak; Li, Lianbo; Liu, Yan;
A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation
Cell discovery
N/A
2016
- Yu, Xiao; Wang, Qi-Long; Li, Yue-Fang;
Wang, Xu-Dong ; Xu, Anlong; Li, Yingqiu;
PKC-theta in vitro Kinase Activity Assay
Bio-protocol
N/A
2016
Wang, Xu-Dong ; Li, Yingqiu;
Assessment of TCR-induced Sumoylation of PKC-theta
Bio-protocol
N/A
2016
Wang, Xu-Dong ; Chen, Zhilong; Wang, Qilong; Li, Yingqiu;
The p38-interacting protein (p38IP) regulates G2/M progression by promoting a-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5
Journal of Biological Chemistry
N/A
2013
- Liu, Xin; Xiao, Wei;
Wang, Xu-Dong ; Li, Yue-Fang; Han, Jiahuai; Li, Yingqiu;
Biomimetic electrodeposition of hydroxyapatite onto TiO2 nanotubes modified by L-aspartic acid
2007 1st International Conference on Bioinformatics and Biomedical Engineering
N/A
2007
- Zhang, Wenjuan; Lu, Chang; Huang, Shaowei;
Wang, Xu-Dong ; Zhu, Zhihong; Huang, Xintang; Zeng, Yan;
Conference Talks
Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells
Lung Cancer SPORE Workshop at National Cancer Institute
Shady Grove, MD, USA
2019
TCR-induced sumoylation of the PKC-theta controls T cell synapse organization and T cell activation
Xiamen Winter Symposium
Xiamen, China
2015
Sumoylation-dependent cSMAC localization of PKCtheta is critical for T cell activation
The 12th Congress of the Chinese Society for Cell Biology
Beijing, China
2011
Honors and Awards
CPRIT Postdoctoral Fellowship
RP160157
N/A
2021 - 2020
Outstanding Graduate Student Scholarship
Sun Yat-sen University
N/A
2015 - 2008
Best Poster
Xiamen Winter Symposium
N/A
2015
Professional Affliations
American Association for Cancer Research
Associate member
N/A
present - 2018
Training of graduate students
Maggie Wang (Ph.D. candidate)
UT Southwestern Medical Center
Dallas, TX, USA
2021.3 - 2021.1
- Walk through of training for MS sample prepration and data analysis
Martyna Kosno (Ph.D. candidate)
UT Southwestern Medical Center
Dallas, TX, USA
2017.11 - 2017.9
- Walk through of training for sub-cellular organelle isolation
- MS sample prepration and data analysis
Chensi Zhao (Ph.D. candidate)
Sun Yat-sen University
Guangzhou, China
2015 - 2011
- Mentoring
Xingzhi Feng (M.S.)
Sun Yat-sen University
Guangzhou, China
2013 - 2010
- Supervising experment design