Aside

Contact

Skills

Mass Spectrometry
Cell culture
Flow cytometry
Molecular cloning
HTS Screening
R
Python

Disclaimer

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Last updated on 2021-03-01.

Main

Xudong Wang, Ph.D. 

My academic training and research experiences have provided me with a solid background in multiple biological disciplines including biochemistry, molecular biology, immunology, and proteomics.
My long-term interest is to employ cutting-edge biotechnologies and computer science to elucidate the fundamental mechanisms of biology systems.

Education

Postdoctoral Researcher

UT Southwestern Medical Center

Dallas, TX, USA

Present - 2015

Ph.D., Biochemistry and Molecular Biology

Sun Yat-sen University

Guangzhou, China

2015 - 2008

B.Sc., Applied Chemistry

School of Chemistry, Central China Normal University

Wuhan, China

2008 - 2004

B.Sc., Biotechnology (Dual degree)

Life Science School, Central China Normal University

Wuhan, China

2008 - 2004

Research Experience

Postdoctoral Research Jobs and Projects

N/A

N/A

Present - 2016

  • Independent development of MS-based assays, data analysis, and presenting data to the team

  • Systematically characterized the mTOR-regulated secretome by a quantitative proteomic approach, deciphering the molecular basis of mTORC1-mediated feedback loops

  • Contributed to mass spectrometry-based screening strategies, including an ultra-fast HTMS screening for identification and characterization small covalent binding molecule modulators to support hit to lead programs from multiple therapeutic areas

Ph.D. Projects

N/A

N/A

2015 - 2008

  • Focused on a novel PTM (sumoylation) in TCR-induced T cell synapse organization and T cell activation

Undergraduate research assistant

N/A

N/A

2008 - 2007

  • In-Vitro Expression and Functional Analyses of TAK1 Isoforms

Other Publications

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

Nucleic Acids Research

N/A

2021

  • Jia, Jian-Jun; Lahr, Roni M; Solgaard, Michael T; Moraes, Bruno J; Pointet, Roberta; Yang, An-Dao; Celucci, Giovanna; Graber, Tyson E; Hoang, Huy-Dung; Niklaus, Marius R; Pena, Izabella A; Hollensen, Anne K; Smith, Ewan M; Chaker-Margot, Malik; Anton, Leonie; Dajadian, Christopher; Livingstone, Mark; Hearnden, Jaclyn; Wang, Xu-Dong; Yu, Yonghao; Maier, Timm; Damgaard, Christian K; Berman, Andrea J; Alain, Tommy; Fonseca, Bruno D

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

Elife

N/A

2020

  • Kim, Chiho; Wang, Xu-Dong; Yu, Yonghao;

Autophagy and Epigenetics

Autophagy and Cardiometabolic Diseases - From Molecular Mechanisms to Translational Medicine

N/A

2018

  • Wang, Xu-Dong; Gillette, Thomas G.; Wang, Zhao V.;

LARP1 is a major phosphorylation substrate of mTORC1

BioRxiv

N/A

2018

  • Fonseca, Bruno D; Jia, Jian-Jun; Hollensen, Anne K; Pointet, Roberta; Hoang, Huy-Dung; Niklaus, Marius R; Pena, Izabella A; Lahr, Roni M; Smith, Ewan M; Hearnden, Jaclyn; Wang, Xu-Dong; Yang, An-Dao; Celucci, Giovanna; Graber, Tyson E; Dajadian, Christopher; Yu, Yonghao; Damgaard, Christian K; Berman, Andrea J; Alain, Tommy

MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis

Molecular cancer

N/A

2017

  • Yang, Yan; Ding, Lili; Hu, Qun; Xia, Jia; Sun, Junjie; Wang, Xu-Dong; Xiong, Hua; Gurbani, Deepak; Li, Lianbo; Liu, Yan;

A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation

Cell discovery

N/A

2016

  • Yu, Xiao; Wang, Qi-Long; Li, Yue-Fang; Wang, Xu-Dong; Xu, Anlong; Li, Yingqiu;

PKC-theta in vitro Kinase Activity Assay

Bio-protocol

N/A

2016

  • Wang, Xu-Dong; Li, Yingqiu;

Assessment of TCR-induced Sumoylation of PKC-theta

Bio-protocol

N/A

2016

  • Wang, Xu-Dong; Chen, Zhilong; Wang, Qilong; Li, Yingqiu;

The p38-interacting protein (p38IP) regulates G2/M progression by promoting a-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5

Journal of Biological Chemistry

N/A

2013

  • Liu, Xin; Xiao, Wei; Wang, Xu-Dong; Li, Yue-Fang; Han, Jiahuai; Li, Yingqiu;

Biomimetic electrodeposition of hydroxyapatite onto TiO2 nanotubes modified by L-aspartic acid

2007 1st International Conference on Bioinformatics and Biomedical Engineering

N/A

2007

  • Zhang, Wenjuan; Lu, Chang; Huang, Shaowei; Wang, Xu-Dong; Zhu, Zhihong; Huang, Xintang; Zeng, Yan;

Conference Talks

Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells

Lung Cancer SPORE Workshop at National Cancer Institute

Shady Grove, MD, USA

2019

TCR-induced sumoylation of the PKC-theta controls T cell synapse organization and T cell activation

Xiamen Winter Symposium

Xiamen, China

2015

Sumoylation-dependent cSMAC localization of PKCtheta is critical for T cell activation

The 12th Congress of the Chinese Society for Cell Biology

Beijing, China

2011

Honors and Awards

CPRIT Postdoctoral Fellowship

RP160157

N/A

2021 - 2020

Outstanding Graduate Student Scholarship

Sun Yat-sen University

N/A

2015 - 2008

Best Poster

Xiamen Winter Symposium

N/A

2015


Professional Affliations

American Association for Cancer Research

Associate member

N/A

present - 2018


Training of graduate students

Maggie Wang (Ph.D. candidate)

UT Southwestern Medical Center

Dallas, TX, USA

2021.3 - 2021.1

  • Walk through of training for MS sample prepration and data analysis

Martyna Kosno (Ph.D. candidate)

UT Southwestern Medical Center

Dallas, TX, USA

2017.11 - 2017.9

  • Walk through of training for sub-cellular organelle isolation
  • MS sample prepration and data analysis

Chensi Zhao (Ph.D. candidate)

Sun Yat-sen University

Guangzhou, China

2015 - 2011

  • Mentoring

Xingzhi Feng (M.S.)

Sun Yat-sen University

Guangzhou, China

2013 - 2010

  • Supervising experment design